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KMID : 0362919920100010069
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1992 Volume.10 No. 1 p.69 ~ p.76
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Analysis of Pretreatment Prognostic Factors in Locally Advanced Carcinoma of the Uterine Cervix
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Oh Do-Hoon
Ha Sung-Whan
Lee Moo-Song
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Abstract
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To identify pretreatment prognostic factors in locally advanced carcinoma of the uterine cervix, retrospective analysis was undertaken of 154 patients treated with curative radiation therapy at Seoul National University Hospital, from March 1979 through December 1980. According to FIGO classification, eight patients were stage ⅢA, 134 were stage ⅢB, and 12 were stage ⅣA. Five year locoregional control rate was 58%, 51%, and 27% in stage ⅢA, ⅢB, and ⅣA, respectively. Five year disease free survival was 57%, 40%, and 25% for each stage respectively. Five year overall survival was 67%, 51%, and 33% in stage ⅢA, ⅢB, and ⅣA, respectively.
In univariate analysis, fewer than or equal to four of pregnancies, initial hemoglobin of lower than 10 g%, and pelvic sidewall invasion on CT were associated with poor locoregional control. Number of pregnancies, initial hemoglobin level, obstructive uropathy on intavenous pyelography(IVP), pelvic lymph node(LN) status on CT, and pelvic sidewall Invasion on CT were significant factors in disease free survival. In terms of overall survival, pelvic sidewall invasion on CT and bladder invasion on CT were prognostically significant.
In multivariate analysis, no factor was found to affect locoregional control and pelvic LN status was a sole significant factor affecting disease free survival. In terms of overall survival, the size of primary tumor was a significant prognosticator.
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KEYWORD
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Cervix cancer, Stage Ⅲ & Ⅳ, Prognostic factor, Radiation therapy
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